Beasley began his career as a musician, playing guitar in a blues band. He received his stage name from an audience member who declared a guitar lick to be, "Killer, Beaz!"
He first performed in 1982 when a bar owner requested a comedian perform. With no real outlets for comedy in his home state, he spent time opening for musical groups and at pool halls. After seeing comedian Jay Leno perform in Chicago in the early 1980s, he had an "epiphany" and relocated to Nashville.
As his career developed, he made hundreds of appearances on The Nashville Network and CMT. He appeared on over 100 television programs and is known for the catchphrase "save up." On the 1996 album NASCAR: Hotter Than Asphalt, Killer Beaz recorded a song called "Save Up" backed up by Lynyrd Skynyrd.
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His first major-label comedy album, Don’t Ever Touch Anybody You Don’t Know, was released in 2013 on Jack Records, an imprint of Warner Bros. Records. Beasley has also appeared on numerous episodes of the television series Moonshiners, alongside friends Mark and Digger.